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FDA-NIH Research Portfolio

This list contains grants and contracts carried over from prior fiscal years and new projects awarded in the current fiscal year for Special Research Priority on U.S. Food and Drug Administration (FDA) Tobacco Product Regulation.

R21 Research Projects for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, PAR-12-266, awarded in fiscal year 2013.
Principal Investigator
Organization
Title Grant Number
Connolly, Gregory Niles
Harvard School of Public Health
A Regulatory Framework for Substantial Equivalence Product Applications under the FSPTCA 1R21DA036485-01
O’Connor, Richard J.
Roswell Park Cancer Institute
Influence of Advertising and Product Type on e-Cigarette Demand among Smokers 1R21DA036476-01
Pearson, Jennifer Lynn
American Legacy Foundation
A Mixed Methods EMA Assessment of Cognition and Behavior among New ENDS Users 1R21DA036472-01
Perkins, Kenneth Alan
University of Pittsburgh at Pittsburgh
Threshold Dose for Nicotine Discrimination in Cigarettes 1R21DA035968-01
Robinson, Risa Jean
Rochester Institute of Technology
Nicotine Emissions, Toxicity, and Behavior by Electronic Cigarettes 1R21DA036057-01
Sterling, Kymberle L.
Georgia State University
Assessing Risk Perceptions of Flavored Small Cigars/Cigarillos Among Young Adults 1R21CA180934-01
Whiteaker, Paul
St. Joseph’s Hospital and Medical Center
High-Throughput Assay Development for Non-Nicotine Tobacco Components 1R21DA036059-01

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R01 Research Projects for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, PAR-12-267, awarded in fiscal year 2013.
Principal Investigator
Organization
Title Grant Number
Berg, Carla J.
Emory University
Market Research to Predict Emerging Tobacco Product Use in Diverse Young Adults 1R01CA179422-01
Guydish, Joseph
University of California San Francisco
Marketing, FDA Communication, Tobacco Perceptions and Use in Addiction Treatment 1R01DA036066-01
Langleben, Daniel D
University of Pennsylvania
Brain and Behavioral Effects of Graphic Cigarette Warning Labels 1R01DA036028-01
Levy, David
Georgetown University
Modeling the Policy Impact of Cigarette and Smokeless Use on U.S. Mortality 1R01DA036497-01
Litt, Mark
University of Connecticut Health Center
Taste, Preferences, and Behavior: Effects of Nicotine and Flavorings in Electronic Cigarettes 1R01DA036492-01
London, Edythe
University of California Los Angeles
Behavioral and Neural Response to Reduced Nicotine Cigarettes in Young Smokers 1R01DA036487-01
Oncken, Cheryl Ann
University of Connecticut Health Center
Manipulating Tobacco Constituents in Female Menthol Smokers 1R01DA036486-01
Srivastava, Sanjay
University of Louisville
Tobacco Products and Atherosclerotic Disease 1R01HL120746-01
Stacy, Alan W. and Ames, Susan
Claremont Graduate University
Marketing and Explanatory Processes in Tobacco Progression among Vulnerable Youth 1R01HD077560-01
Stepanov, Irina
University of Minnesota
Constituent Yields and Biomarkers of Exposure for Tobacco Product Regulation 1R01CA179246-01
Strasser, Andrew
University of Pennsylvania
Using Eye Tracking to Understand and Improve Graphic Warning Label Effectiveness 1R01CA180929-01

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R03 Research Projects for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, PAR-12-268, awarded in fiscal year 2013.
Principal Investigator
Organization
Title Grant Number
Norton, Edward C.
University of Michigan
Improving Cost-Benefit Analysis of Tobacco Regulation 1R03CA182990-01

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Investigator Initiated Projects for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, awarded in fiscal year 2013.
Principal Investigator
Organization
Title Grant Number
Ayers, John W.
Children’s Hospital Boston
Tobacco Trends: A Real-Time Sentinel for Tobacco Control Evaluations 1R21CA173299-01
Banerjee, Smita
Sloan-Kettering Institute for Cancer Research
Exploring Persuasiveness of Non Cigarette Tobacco Product (NCTP) Advertising on Young Adults 1R03DA035242-01
Mukhin, Alexey G.
Duke University
Alpha 5 Nicotonic Receptor Subunit Gene Polymorphisms and Smoking Addiction 1R01DA034862-01
Shadel, William G.
Rand Corporation
Reducing the Effect of Tobacco Powerwall Displays at Retail Point-of-Sale 1R01CA175209-01
Siahpush, Mohammed
University of Nebraska Medical Center
The Effect of Point-of-Sale Tobacco Marketing on Smoking Cessation 1R01CA166156-01A1
Staimer, Norbert
University of California Irvine
Differential Redox & Electrophilic Toxicities of Modified Tobacco Products 1R21CA164540-01A1
Wackowski, Olivia
University of Medicine and Dentistry of New Jersey
Exploring Smokers' Perceptions of Differing Smokeless Tobacco News Messages 1R03CA175901-01

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Administrative Supplements for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, awarded in fiscal year 2013.

The grant titles and research descriptions reflect the parent awards. We are in the process of updating this content with the tobacco regulatory research being conducted through the administrative supplement.

Principal Investigator
Organization
Title Grant Number
Cummings, Michael
Medical University of South Carolina
Effectiveness of Tobacco Control Policies in High vs. Low Income Countries 3P01CA138389-06S1
Donny, Eric Christian
University of Pittsburgh at Pittsburgh
Evaluating New Nicotine Standards for Cigarettes 3U54DA031659-02S1
Fiore, Michael C.
University of Wisconsin
A Comparative Effectiveness and Long-term Health Study in Wisconsin Smokers 3R01HL109031-02S1
Fiore abstract.pdf
(PDF - 12KB)
Hamilton, Carol
Research Triangle Institute
Genomic Resource Grant for PhenX Toolkit (U41) 3U41HG007050-01S1
Valente, Thomas W.
University of Southern California
The Global Diffusion of Tobacco Control 3R01CA157577-02S1

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Intramural Projects for Special Research Priority on U.S. Food and Drug Administration (FDA) Tobacco Product Regulation awarded in fiscal year 2013.
Principal Investigator
Organization
Title Abstract
Abnet, Christian
National Cancer Institute (NCI)
Impact of tobacco oral health and the oral microbiome Abnet abstract.pdf
(PDF - 48.3 KB)
Bell, Douglas
National Institute of Environmental Health Sciences (NIEHS)
Epigenetic biomarkers of tobacco smoke exposure Bell abstract.pdf
(PDF - 55.2 KB)
Boehm, Manfred
National Heart, Lung and Blood Institute (NHLBI)
Genetics of cellular sensitivity to tobacco compounds Boehm abstract.pdf
(PDF - 50.0 KB)
Drayna, Dennis
National Institute on Deafness and Other Communication Disorders (NIDCD)
Genetic factors in taste perception and tobacco usage Drayna abstract.pdf
(PDF - 49.0 KB)
London, Stephanie
National Institute of Environmental Health Sciences (NIEHS)
Maternal smoking in pregnancy, methylation and asthma in offspring London abstract.pdf
(PDF - 16 KB)
Schrump , David
National Cancer Institute (NCI)
Epigenomic effects of hookah tobacco smoke in human respiratory epithelia Schrump abstract.pdf
(PDF - 52.6 KB)
Stein, Elliot
National Institute on Drug Abuse (NIDA)
Multimodel neuroimaging genetic biomarkers of nicotine addiction Stein abstract.pdf
(PDF - 49.2 KB)
Wainer, Irving
National Institute on Aging (NIA)
Identification of active component patterns in tobacco smoke Wainer abstract.pdf
(PDF - 49.1 KB)

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Investigator Initiated for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation awarded in fiscal year 2012.
Principal Investigator
Organization
Title Grant Number
Blalock, J. Edwin
University of Alabama at Birmingham
PGP, A Possible Biomarker for COPD Exacerbations and or Progression 1R01HL114439-01
Buehler, Stephanie S
Battelle Centers/Public Health Research and Evaluation
Real-Time Measurement and Uptake of Carcinogens by Menthol Cigarette Smokers 5R01CA162085-02
Clark, Pamela I.
University of Maryland College Park Campus
Rapid response human testing of smokeless tobacco products 1R01DA031142-01A1
Crystal, Ronald G
Weill Medical College of Cornell University
COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function 1P20HL113443-01
Cummings, K. Michael
Medical University of South Carolina
Effectiveness of tobacco control policies in high vs. low income countries 3P01CA138389-05S1
(Admin Supplement)
Delnevo, Cristine D.
University of Medicine and Dentistry of New Jersey School of Public Health
Measurement of Tobacco Use among South Asians in the U.S 1R21CA164913-01A1
Donny, Eric Christian
University of Pittsburgh at Pittsburgh
Evaluating New Nicotine Standards for Cigarettes 5U54DA031659-02
Hatsukami, Dorothy K.
University of Minnesota Twin Cities
Models For Tobacco Product Evaluation 1U19CA157345-01A1
Mays, Darren M.
Georgetown University
Framing Messages for Teen Smoking Prevention in Primary Care 1R03CA162839-01A1
Nasim, Aashir
Virginia Commonwealth University
Cigarillo smoking: smoke toxicant content and user toxicant exposure and effects R21CA161317-01A1
Pickworth, Wallace Bruce
Battelle Centers/Public Health Research and Evaluation
Mainstream Smoke Composition and Toxin Exposure from Prototypical Cigar Products 1R01CA158045-01A1
Rice, Virginia Hill
Wayne State University
Health Effects of Adolescent Water Pipe Smoking with & without Cigarette Smoking 1R15DA032822-01
Romer, Daniel
University of Pennsylvania
Communicating Smoking Risks Through Graphic Warning Labels 1R01CA157824-01A1
Sterling, Kymberle L.
Georgia State University
Developing Measures of Little Cigar Use for Young Adults 1R03CA159909-01A1
Timberlake, David
University of California Irvine
Should Smokeless Tobacco be Promoted as an Alternative for Smokers ? 1R03DA027950-01A1
Trumbo, Craig W.
Colorado State University Fort Collins
Social Normative Conditions and the Diffusion of Electronic Nicotine Delivery Sys 1R03DA033578-01
Van Der Vliet, Albert
University of Vermont and State Agriculture College
Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation 1R01ES021476-01
Williams, Rebecca S.
University of North Carolina Chapel Hill
Evaluating the Impact of Federal Legislation on Internet Tobacco Sales 1R01CA169189-01
Zou, Ming-Hui
University of Oklahoma Health Sciences Center
AMPK as a redox sensor and modulator 2R01HL089920-05


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Program Projects Administrative Supplements for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, NOT-CA-12-007, awarded in fiscal year 2012.

The grant titles and research descriptions reflect the parent awards. We are in the process of updating this content with the tobacco regulatory research being conducted through the administrative supplement.

Principal Investigator
Organization
Title Grant Number
Carroll, Kathleen
Yale University
Psychotherapy Development Research Center 3P50DA009241-19S1
Fiore, Michael & Baker, Tim
University of Wisconsin
Engineering Effective Interventions for Tobacco Use 3P50CA143188-14S1
Guydish, Joseph
University of California San Francisco
Treatment for Complex Patients: Continuing and Extended Care 3P50DA009253-18S1
Malhotra, Anil
Feinsein Institute for Medical Research
Dissecting Heterogeneity of Treatment Response of First Episode Schizophrenia 3P50MH080173-05S2
Mermelstein, Robin
University of Illinois and Chicago
Social-Emotional Contexts of Adolescent Smoking Patterns 3P01CA098262-08S1
Murry, Charles
University of Washington
Stem Cells and Cardiovascular Repair 3P01HL094374-03S1
Ziegler, Steven
Benaroya Institute
Regulation of pulmonary inflammation by leukocytes and extracellular matrix 3P01HL098067-03S1

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R01 Competitive Revisions for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, PAR-12-010, awarded in fiscal year 2012.

The grant titles and research descriptions reflect the parent awards. We are in the process of updating this content with the tobacco regulatory research being conducted through the competitive revision.

Principal Investigator
Organization
Title Grant Number
Andrews, Judy A
Oregon Research Institute
Childhood and Adolescent Predictors of Substance Abuse in Emerging Adulthood 3R01DA010767-14S2
Chassin, Laurie
Arizona State University Tempe Campus
Teen & Adult Smoking: Intergenerational Transmission and Prevention Applications 3R01DA13555-30S1
Crystal, Ronald G.
Weill Medical College of Cornell University
Overlapping Airway Basal Cell Transcriptome Reprogramming in COPD and Lung Cancer 3R01HL107882-2S1
Ding, Xinxin
Wadsworth Center
Human CYP2A and respiratory tract xenobiotic toxicity 3R01CA92596-9S1
Haddock, Christopher Keith
National Development and Research Institutes
Barriers to Effective Tobacco Control Policy Implementation in the US Military 3R01CA109153-7S1
Hecht, Stephen S.
University of Minnesota Twin Cities
Metabolism of Carcinogenic Tobacco-Specific Nitrosamines 3R37CA81301-14S1
Jordt, Sven-Eric
Yale University
Counter-irritation by Menthol: Molecular Targets and Role in Airway Disease 3R01HL105635-02S1
Jordt abstract.pdf
(PDF - 26.4 KB)
Klesges, Robert C.
University of Tennessee Health Science Center
Predictors of Smokeless Tobacco and Dual Use in the US Military 3R01CA141567-4S1
Latkin, Carl A.
Johns Hopkins University
A comprehensive approach to secondary HIV prevention and care among positives 3R01DA32217-2S1
Turesky, Robert J.
Wadsworth Center
2-Amino-9H-pyrido(2,3-b)indole: a potential colorectal carcinogen formed in tobacco 3R01CA134700-3S1
Wewers, Mary Ellen
Ohio State University
Tobacco cessation interventions with Ohio Appalachian smokers 3R01CA129771-03S1
Wolfson, Mark
Wake Forest University Health Sciences
Smokeless Tobacco Use in College Students 3R01CA141643-4S2

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U01 Competitive Revisions for Special Research Priority on U.S Food and Drug Administration (FDA) Tobacco Product Regulation, PAR-12-011, awarded in fiscal year 2012.

The grant titles and research descriptions reflect the parent awards. We are in the process of updating this content with the tobacco regulatory research being conducted through the competitive revision.

Principal Investigator
Organization
Title Grant Number
Bailey, William C.
University of Alabama at Birmingham
Who and Why cigarette smokers use e-cigarettes after hospitalization 3U01DA31515-3S1
Dubinett, Steven M.
University of California Los Angeles
The UCLA - Boston University Lung Cancer Biomarker Development Laboratory 3U01CA152751-3S1
Lerman, Caryn
University of Pennsylvania
Pharmacogenetics of Nicotine Addiction Treatment 3U01DA20830-8S1

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Communication Administrative Supplements for Special Research Priority on U.S. Food and Drug Administration (FDA) Tobacco Product Regulation awarded in fiscal year 2012.

We are in the process of updating the content with the tobacco regulatory research being conducted through the administrative supplement.

Principal Investigator
Organization
Title Grant Number
Hornik, Robert
University of Pennsylvania
Supporting the diffusion of the tobacco graphic warning labels 3P20CA095856-09S1
Kreuter, Matthew W.
Washington University in St. Louis
Understanding reactions to graphic warning labels on cigarettes in diverse populations of youth and young adults at increased risk of smoking 3P50CA095815-09S1
Williams, David R.
Harvard University
Assessing and Magnifying the Impact of Cigarette Pack Health Warnings among Vulnerable Populations: An Integrated Study 3P50CA148596-03S1

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Administrative Supplements for Special Research Priority on U.S. Food and Drug Administration (FDA) Tobacco Product Regulation, NOT-CA-10-007, awarded in fiscal year 2010.

The grant titles and research descriptions reflect the parent awards. We are in the process of updating this content with the tobacco regulatory research being conducted through the administrative supplement.

Principal Investigator
Organization
Title Grant Number
Connolly, Gregory N.
Harvard School of Public Health
Subjective and Behavioral Responses to PREP Design and Marketing: Modification of risk perceptions of light cigarettes 3R01CA125224-03S1
Cummings, K. Michael
Roswell Park Cancer Institute
Effectiveness of Tobacco Control Policies in High vs. Low Income Countries 3P01CA138389-02S
Fong, Geoffrey T.
University of Waterloo
International Tobacco Policy Surveys 3R01CA100362-05S1
Forster, Jean
University of Minnesota
The Effects of Minnesota State and Local Programs on Young Adult Tobacco Use 3R01CA086191-10A1S1
Hatsukami, Dorothy K.
University of Minnesota
Novel Determinants of Measures of Smokeless Tobacco Use 3R01CA141531-02S1
Henriksen, Lisa A.
Stanford University
Impact of Retail Tobacco Advertising on Youth Smoking 3R01CA067850-10A1S1
Ling, Pamela M.
University of California San Francisco
Understanding Smokeless Tobacco Marketing 3R01CA141661-02S1
Strasser, Andrew A.
Stanford University
Smoking Topography and Harm Exposure in a New PREP 3R01CA120594-04S1

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These contracts are also supported by the FDA Center for Tobacco Products.

Population Assessment of Tobacco and Health (PATH) Study
In October 2011, the Food and Drug Administration (FDA) and the National Institutes of Health (NIH) announced a joint national, prospective, longitudinal cohort study of tobacco users and those at risk for tobacco-product use to monitor and assess their tobacco use and the resultant health impacts. The initiative, called the Population Assessment of Tobacco and Health (PATH) Study, represents the first large-scale NIH-FDA collaboration on tobacco regulatory research since Congress granted FDA the authority to regulate tobacco products under the Family Smoking Protection and Tobacco Control Act (FSPTCA). Scientific experts at the National Institute on Drug Abuse (NIDA) and FDA’s Center for Tobacco Products (CTP) will coordinate this effort via a research contract awarded to Westat in Rockville, MD.

The PATH Study will prospectively follow almost 60,000 people who are users of tobacco products and those at risk for tobacco-product use ages 12 and older in the United States. The study will a) examine what makes people susceptible to tobacco-product use; b) evaluate initiation and use patterns including use of new products, dual use, poly use, and switching of tobacco products; c) study patterns of tobacco-product cessation and relapse ; d) evaluate the effects of regulatory changes on risk perceptions and other tobacco-related attitudes; and e) assess differences in attitudes, behaviors, and key health outcomes among racial/ethnic, gender, and age subgroups. The PATH Study will also collect biospecimens from adults to analyze biomarkers of tobacco use and disease processes.

By measuring and accurately reporting on the social, behavioral and health effects associated with tobacco-product use in the U.S., the PATH Study will provide an empirical evidence base to inform the development and assessment of tobacco-product regulations by the FDA.

Other NIH Tobacco-Related Research

NIH funds other tobacco-related research. For a complete portfolio of NIH-supported tobacco research visit the NIH Research Portfolio Online Reporting Tools Expenditures and Results (NIH RePORT).