NIH: Office of Disease Prevention

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In controlled intervention trials, a hypothesis is tested using methods designed to examine the efficacy or effectiveness of an intervention in a group or population. This phase is necessary to determine if the intervention is suitable to be tested on a larger scale.

  • Head Start REDI Classroom and Home Visiting Program
    Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
    The aim of the study is to assess the long-term impact of the REDI (Research-based, Developmentally Informed) classroom program to enhance teaching quality on academic attainment and reductions in risky behaviors in adolescence as well as the longer-term impact of the complementary REDI home visiting program.
  • Exercise, Aging and Cognition
    National Institute on Aging (NIA)
    Evidence suggests that exercise can have a beneficial effect on cognition in older adults. Earlier intervention using exercise may prevent age-related changes in cognition. This study seeks to extend the investigation to younger individuals, aged 25 to 40 and 50 to 65.
  • Hearing Health Education Programs for Farm and Rural Youth
    National Institute on Deafness and Other Communication Disorders (NIDCD)
    Farm and rural youth have an increased prevalence of noise-induced hearing loss. The purpose of this project is to test innovative hearing health education programs delivered to a large target group and to determine the effectiveness and sustainability of these programs in promoting hearing health among farm and rural youth.
  • Women's Health Initiative
    National Heart Lung and Blood Institute (NHLBI)
    The Women's Health Initiative was established in 1991 to address the most common causes of death, disability, and impaired quality of life in postmenopausal women. The study includes clinical trials and interventions for the prevention of cardiovascular disease, cancer, and osteoporosis.
  • The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    National Cancer Institute (NCI)
    This study is a large population-based randomized trial designed to determine the effects of screening on cancer-related deaths and secondary endpoints, such as occurrence of disease or symptoms, in adults aged 55 to 74. These efforts could ultimately lead to new prevention measures.
  • National Lung Screening Trial
    National Cancer Institute (NCI)
    This randomized trial compares the effects of two screening procedures for lung cancer in current and former heavy smokers ages 55 to 74. The purpose of this study is to examine if screening for lung cancer reduces deaths among the trial participants.
  • Prevention of Age-Related Eye Disease Using Vitamins and Minerals
    National Eye Institute (NEI)
    Age-related macular degeneration is the leading cause of vision loss in the United States for people over the age of 60. This nationwide, long-term study sets out to determine whether a modified combination of vitamins and minerals can further slow the progression of vision loss from this disease.
  • The ASPIRE HIV Prevention Study
    National Institute of Allergy and Infectious Diseases (NIAID)
    This study, "A Study to Prevent Infection with a Ring for Extended Use," examines the safety and effectiveness of a vaginal ring for the prevention of HIV infections in women. The trial will be launched at several sites in Africa and will enroll approximately 3500 women. If successful, this vaginal ring, which contains the antiretroviral dapivirine, can be used for HIV prevention.