Funded Research: Tobacco Centers of Regulatory Science

The Tobacco Centers of Regulatory Science (TCORS) are the centerpiece of the Tobacco Regulatory Science Program. The 14 TCORS, funded from RFA-DA-13-003, generate critical research that informs the FDA’s regulation of tobacco products. Essential elements of the TCORS include:

  • At least three theoretically grounded, strong research projects with an integrative theme;
  • An Administrative Core and other cores as needed; the ability to conduct developmental/pilot and time-sensitive research; and
  • A program for career development and training

Currently Funded Centers: TCORS 2013-2018

The 14 TCORS, made up of scientists with a broad range of expertise (e.g., epidemiology, economics, toxicology, addictions, and marketing), include:

American Heart Association Tobacco Regulation and Addiction Center (A-TRAC) (PDF - 38 KB)

Grant Information Project Details and Abstract Links

Principal Investigators:
Aruni Bhatnagar, Ph.D., and
Rose M. Robertson, M.D.

Organization:
American Heart Association, Dallas

Grant Number:
P50-HL-120163-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Cardiovascular Toxicity of Tobacco Products (PDF - 33 KB)
Research Project Director: Sanjay Srivastava, University of Louisville

Project 2: Cardiovascular Injury Due to Tobacco Use (PDF - 34 KB)
Research Project Director: Aruni Bhatnagar, University of Louisville, American Heart Association

Project 3: Perception of Tobacco Use in Vulnerable Populations (PDF - 34 KB)
Research Project Director: Herman Taylor, University of Mississippi

Rapid Response Characterization of New and Manipulated Tobacco Products (PDF - 42 KB)

Grant Information Project Details and Abstract Links

Principal Investigator:
Pamela I. Clark, Ph.D.

Organization:
University of Maryland, College Park

Grant Number:
P50-CA-180523-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Toxicity Testing of New and Manipulated Tobacco Products (PDF - 17 KB)
Research Project Director: Courtney A. Granville, Battelle

Project 2: Consumer Acceptability Testing of New and Manipulated Tobacco Products (PDF - 17 KB)
Research Project Director: Pamela I. Clark, University of Maryland

Project 3: Exploring Tobacco Microbial Constituents and the Oral Microbiome of Tobacco Users (PDF - 16 KB)
Research Project Directors: Amy R. Sapkota, University of Maryland; Emmanuel F. Mongodin, University of Maryland

Center for the Study of Tobacco Products (PDF - 22 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Thomas E. Eissenberg, Ph.D., and Robert Balster, Ph.D.

Organization:
Virginia Commonwealth University, Richmond

Grant Number:
P50-DA-036105-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Analytical Lab Methods for Modified Risk Tobacco Products (MRTP) Evaluation (PDF - 32 KB)
Research Project Director: Alan Shihadeh, American University of Beirut

Project 2: Human Lab Methods for MRTP Evaluation (PDF - 31 KB)
Research Project Directors: Alison Breland, Virginia Commonwealth University;
Michael Weaver, Virginia Commonwealth University

Project 3: Randomized Control Trial Methods for MRTP Evaluation (PDF - 34 KB)
Research Project Director: Thomas E. Eissenberg, Virginia Commonwealth University; Jonathan Foulds, Pennsylvania State University

Project 4: Quantitative and Qualitative Methods for MRTP Evaluation (PDF - 33 KB)
Research Project Director: Aashir Nasim, Virginia Commonwealth University

The Science of Decision Making: Connecting People and Policy (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Michael P. Eriksen, Ph.D.

Organization:
Georgia State University, Atlanta

Grant Number:
P50-DA-036128-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Enhancing the Economic Impact Analysis Used in FDA's Rules for Tobacco Products (PDF - 34 KB)
Research Project Director: Frank J. Chaloupka, University of Illinois at Chicago

Project 2: Testing Tobacco Ad Restrictions and Counterads in a 3D Virtual Retail Store (PDF - 34 KB)
Research Project Director: Matthew Farrelly, RTI International

Project 3: Conducting Consumer Behavior, Risk Perception and Media Research on Novel Tobacco Products (PDF - 34 KB)
Research Project Director: 

Improved Models to Inform Tobacco Product Regulation (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Stanton A. Glantz, Ph.D.

Organization:
University of California-San Francisco

Grant Number:
P50-CA-180890-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Impact of Changing Tobacco Product Use on Tobacco-Related Disease and Healthcare Costs (PDF - 32 KB)
Research Project Director: Wendy Max, University of California, San Francisco

Project 2: The Role of Risk and Benefit Perceptions in Tobacco Control and Product Usage (PDF - 33 KB)
Research Project Directors: Bonnie Halpern-Felsher, University of California, San Francisco; Pamela Ling, University of California, San Francisco

Project 3: Smokeless Tobacco Use among Rural High School Males and Resulting Nicotine and Carcinogen Exposure (PDF - 30 KB)
Research Project Director: Margaret Walsh, University of California, San Francisco

Project 4: Quantification and Biomarkers of Short-Term Pulmonary Effects of Tobacco Smoke Exposure: Infection-Related Acute Lung Injury (PDF - 35 KB)
Research Project Directors: Carolyn Calfee, University of California, San Francisco; Michael Matthay, University of California, San Francisco

Project 5: Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products (PDF - 30 KB)
Research Project Directors: Peter Ganz, University of California, San Francisco; Suzaynn Schick, University of California, San Francisco

Vermont Center on Tobacco Regulatory Science (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Stephen T. Higgins, Ph.D.

Organization:
University of Vermont and State Agriculture College, Burlington

Grant Number:
P50-DA-036114-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Low Nicotine Cigarettes in Vulnerable Populations: Childbearing Age Women (PDF - 18 KB)
Research Project Directors: Sarah H. Heil, University of Vermont; Stephen T. Higgins, University of Vermont

Project 2: Low-Nicotine Cigarettes in Vulnerable Populations: Opioid Abusers (PDF - 18 KB)
Research Project Director: Stacey C. Sigmon, University of Vermont

Project 3: Low-Nicotine Cigarettes in Vulnerable Populations: Currently Depressed (PDF - 14 KB)
Research Project Director: Jennifer W. Tidey, Brown University

UPENN TCORS: Tobacco Product Messaging in a Complex Communication Environment (PDF - 14 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Robert C. Hornik, Ph.D., and Caryn Lerman, Ph.D.

Organization:
University of Pennsylvania, Philadelphia

Grant Number:
P50-CA-179546-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Information and Misleading Information about Tobacco Products in the "New" and "Old" Public Communication Environment: Measuring Its Presence, Estimating Its Effects, Recommending Regulatory Responses (PDF - 33 KB)
Research Project Director: Robert Hornik, University of Pennsylvania

Project 2: Belief Echoes: Interventions to Correct Misleading Information about Tobacco Products (PDF - 46 KB)
Research Project Director: Joseph N. Cappella, University of Pennsylvania

Project 3: Effects of Implicit Messaging by Cigarette Pack Color on Smoking Behaviors (PDF - 31 KB)
Research Project Director: Andrew A. Strasser, University of Pennsylvania

Yale Tobacco Center of Regulatory Science (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Suchitra Krishnan-Sarin, Ph.D., and
Stephanie S. O’Malley, Ph.D.

Organization:
Yale University, New Haven

Grant Number:
P50-DA-036151-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Effects of Flavors on Nicotine Choice and Central Reward Mechanisms (PDF - 33 KB)
Research Project Directors: Sven-Eric Jordt, Yale University; Marina R. Picciotto, Yale University

Project 2: Menthol's Effects on the Nicotine Reinforcement in Smokers (PDF - 33 KB)
Research Project Director: Mehmet Sofouglu, Yale University

Project 3: Flavors and E-cigarette Effects in Adolescent Smokers (PDF - 32 KB)
Research Project Director: Suchitra Krishnan-Sarin, Yale University

Project 4: Economics, Experiments and PATH Data: Creating Knowledge for Tobacco Regulation (PDF - 34 KB)
Research Project Director: Jody L. Sindelar, Yale University

Pennsylvania State University Tobacco Center of Regulatory Science (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Joshua E. Muscat, Ph.D., and
Jonathan Foulds, Ph.D.

Organization:
Penn State College of Medicine/Penn State Milton S. Hershey Medical Center, Hershey

Grant Number:
P50-DA-036107-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Switching to Progressively Reduced Nicotine Content Cigarettes in Smokers with Lower Socioeconomic Status (PDF - 14 KB)
Research Project Director: Joshua E. Muscat, Pennsylvania State University

Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety Disorders (PDF - 14 KB)
Research Project Directors: Jonathan Foulds, Pennsylvania State University; Eden A. Evins, Harvard University

Project 3: Free Radical Exposure and Oxidative Stress from Conventional and Reduced Nicotine Cigarettes (PDF - 15 KB)
Research Project Director: John Richie, Pennsylvania State University

USC Tobacco Center of Regulatory Science for Vulnerable Populations (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Mary Ann Pentz, Ph.D., and
Jonathan M. Samet, M.D.

Organization:
University of Southern California, Los Angeles

Grant Number:
P50-CA-180905-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Diffusion of Marketing Messages about Tobacco Products through Social Media (PDF - 35 KB)
Research Project Directors: Jennifer Unger, University of Southern California; N. Tess Boley Cruz, University of Southern California

Project 2: Maximizing Retailers' Responsiveness to FDA Regulatory Authority in Minority Communities (PDF - 34 KB)
Research Project Director: Lourdes Baezconde-Garbanati, University of Southern California

Project 3: Adolescent Smoking: Vulnerability to Tobacco Use and Marketing across Life (PDF - 35 KB)
Research Project Director: Rob McConnell, University of Southern California

Tobacco Center of Regulatory Science on Youth and Young Adults (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Cheryl L. Perry, Ph.D.

Organization:
The University of Texas Health Sciences Center, Houston

Grant Number:
P50-CA-180906-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Texas Adolescent Tobacco and Marketing Surveillance Study (TATAMS) (PDF - 35 KB)
Research Project Director: Melissa H. Stigler, The University of Texas Health Sciences Center at Houston

Project 2: Tobacco Marketing and Alternative Tobacco Use among College Students (PDF - 39 KB)
Research Project Directors: Alexandra Loukas, The University of Texas at Austin

Project 3: Informing and Correcting Perceptions Regarding Tobacco Products in Young Adults (PDF - 41 KB)
Research Project Director: Alexander V. Prokhorov, The University of Texas MD Anderson Cancer Center

Effective Communication on Tobacco Product Risk and FDA Authority (PDF - 13 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Kurt M. Ribisl, Ph.D.

Organization:
University of North Carolina at Chapel Hill

Grant Number:
P50-CA-180907-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Communicating the Risks of Harmful Cigarette Smoke Constituents (PDF - 39 KB)
Research Project Director: Noel T. Brewer, The University of North Carolina at Chapel Hill

Project 2: Effective Risk Communication on New and Emerging Tobacco Products (PDF - 40 KB)
Research Project Director: Erin L. Sutfin, Wake Forest University

Project 3: Enhancing Source Credibility in Tobacco Regulatory Communications (PDF - 40 KB)
Research Project Director: Adam O. Goldstein, The University of North Carolina at Chapel Hill

OSU Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) (PDF - 14 KB)

Grant Information

Project Details and Abstract Links

Principal Investigators:
Peter G. Shields, M.D., and
Mary Ellen Wewers, Ph.D.

Organization:
The Ohio State University, Columbus

Grant Number:
P50-CA-180908-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Urban and Rural Male Youth Cohort Study of Tobacco Use (PDF - 33 KB)
Research Project Director: Amy Ferketich, The Ohio State University

Project 2: Understanding Adolescent Trajectories, Exposures and Susceptibilities (PDF - 34 KB)
Research Project Director: Peter G. Shields, The Ohio State University

Project 3: Diversity of Tobacco Products Used and Purchased (PDF - 33 KB)
Research Project Director: Mary Ellen Wewers, The Ohio State University

Project 4: Comprehension of Health Risks in More and Less Arousing Affective Contexts (PDF - 33 KB)
Research Project Director: Ellen Peters, The Ohio State University

The Impact of Tobacco Exposure on the Lung's Innate Defense System (PDF - 37 KB)

Grant Information

Project Details and Abstract Links

Principal Investigator:
Robert Tarran, Ph.D.

Organization:
University of North Carolina at Chapel Hill, School of Medicine.

Grant Number:
P50-HL-120100-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Effects of New and Emerging Tobacco Products on Lung Hydration and Inflammation (PDF - 33 KB)
Research Project Director: Robert Tarran, The University of North Carolina at Chapel Hill

Project 2: The Effects of Tobacco Exposure on the Airway Mucus/Mucin Integrity and Proteome: Determining the Tobacco Mucomarkers (PDF - 35 KB)
Research Project Director: Mehmet Kesimer, The University of North Carolina at Chapel Hill

Project 3: Mouse Models of Smoking-related Diseases: What is the Best Mimic of Human Disease? (PDF - 69 KB)
Research Project Director: Claire M. Doerschuk, The University of North Carolina at Chapel Hill

Project 4: Translational Studies to Identify Epithelial Biomarkers of Smoke Exposure (PDF - 34 KB)
Research Project Director: Ilona Jaspers, The University of North Carolina at Chapel Hill