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P50 Tobacco Centers of Regulatory Science (TCORS), RFA-DA-13-003

The Tobacco Regulatory Science Program, located in the NIH Office of Disease Prevention, coordinates the trans-NIH collaborative effort with the Food and Drug Administration (FDA) Center for Tobacco Products to conduct research that is needed  to ensure that U.S. tobacco regulatory actions and activities are based on sound and relevant scientific evidence. The P50 Tobacco Centers of Regulatory Science (TCORS) are the centerpiece of this NIH-FDA collaboration. 

The TCORS are expected to demonstrate research excellence and leadership in tobacco regulatory science that will contribute to the science base that FDA will use to develop meaningful product regulation, which will in turn reduce the toll of tobacco-related disease, disability, and death in the United States. Essential elements of the TCORS include at least three theoretically grounded, strong research projects with an integrative theme; an Administrative Core and other cores as needed; the ability to conduct developmental/pilot and time-sensitive research; and a program for career development and training.

Fourteen TCORS, made up of scientists with a broad range of expertise (e.g., epidemiology, economics, toxicology, addictions, and marketing) have been funded. More information about each of these fourteen TCORS is found below:



American Heart Association Tobacco Regulation and Addiction Center (A-TRAC) (PDF - 37KB)

Principal Investigators:
Aruni Bhatnagar, Ph.D., and
Rose M. Robertson, M.D.

Organization:
American Heart Association, Dallas

Grant Number:
P50-HL-120163-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Cardiovascular Toxicity of Tobacco Products (PDF - 30KB)
Research Project Director: Sanjay Srivastava, University of Louisville

Project 2: Cardiovascular Injury Due to Tobacco Use (PDF - 31KB)
Research Project Director: Aruni Bhatnagar, University of Louisville, American Heart Association

Project 3: Perception of Tobacco Use in Vulnerable Populations (PDF - 30KB)
Research Project Director: Herman Taylor, University of Mississippi

Rapid Response Characterization of New and Manipulated Tobacco Products (PDF - 41KB)

Principal Investigator:
Pamela I. Clark, Ph.D.

Organization:
University of Maryland, College Park

Grant Number:
P50-CA-180523-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Toxicity Testing of New and Manipulated Tobacco Products (PDF - 12KB)
Research Project Director: Courtney A. Granville, Battelle

Project 2: Consumer Acceptability Testing of New and Manipulated Tobacco Products (PDF - 12KB)
Research Project Director: Pamela I. Clark, University of Maryland

Project 3: Exploring Tobacco Microbial Constituents and the Oral Microbiome of Tobacco Users (PDF - 13KB)
Research Project Directors: Amy R. Sapkota, University of Maryland; Emmanuel F. Mongodin, University of Maryland

Center for the Study of Tobacco Products (PDF - 12KB)

Principal Investigators:
Thomas E. Eissenberg, Ph.D., and Robert Balster, Ph.D.

Organization:
Virginia Commonwealth University, Richmond

Grant Number:
P50-DA-036105-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Analytical Lab Methods for MRTP Evaluation (PDF - 29KB)
Research Project Director: Alan Shihadeh, American University of Beirut

Project 2: Human Lab Methods for MRTP Evaluation (PDF - 27KB)
Research Project Directors: Alison Breland, Virginia Commonwealth University;
Michael Weaver, Virginia Commonwealth University

Project 3: Randomized Control Trial Methods for MRTP Evaluation (PDF - 30KB)
Research Project Director: Thomas E. Eissenberg, Virginia Commonwealth University; Jonathan Foulds, Pennsylvania State University

Project 4: Quantitative and Qualitative Methods for MRTP Evaluation (PDF - 30KB)
Research Project Director: Aashir Nasim, Virginia Commonwealth University

The Science of Decision Making: Connecting People and Policy (PDF - 12KB)

Principal Investigator:
Michael P. Eriksen, Ph.D.

Organization:
Georgia State University, Atlanta

Grant Number:
P50-DA-036128-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Enhancing the Economic Impact Analysis used in FDA’s Rules for Tobacco Products (PDF - 30KB)
Research Project Director: Frank J. Chaloupka, University of Illinois at Chicago

Project 2: Testing Tobacco Ad Restrictions and Counterads in a 3D Virtual Retail Store (PDF - 30KB)
Research Project Director: Matthew Farrelly, RTI International

Project 3: Conducting Consumer Behavior, Risk Perception and Media Research on Novel Tobacco Products(PDF - 30KB)
Research Project Director: Michael P. Eriksen, Georgia State University

Improved Models to Inform Tobacco Product Regulation (PDF - 11KB)

Principal Investigator:
Stanton A. Glantz, Ph.D.

Organization:
University of California-San Francisco

Grant Number:
P50-CA-180890-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Impact of Changing Tobacco Product Use on Tobacco-Related Disease and Healthcare Costs (PDF - 27KB)
Research Project Director: Wendy Max, University of California, San Francisco

Project 2: The Role of Risk and Benefit Perceptions in Tobacco Control and Product Usage (PDF - 30KB)
Research Project Directors: Bonnie Halpern-Felsher, University of California, San Francisco; Pamela Ling, University of California, San Francisco

Project 3: Smokeless Tobacco Use among Rural High School Males and Resulting Nicotine and Carcinogen Exposure (PDF - 27KB)
Research Project Director: Margaret Walsh, University of California, San Francisco

Project 4: Quantification and Biomarkers of Short-Term Pulmonary Effects of Tobacco Smoke Exposure: Infection-Related Acute Lung Injury (PDF - 30KB)
Research Project Directors: Carolyn Calfee, University of California, San Francisco; Michael Matthay, University of California, San Francisco

Project 5: Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products (PDF - 27KB)
Research Project Directors: Peter Ganz, University of California, San Francisco; Suzaynn Schick, University of California, San Francisco

Vermont Center on Tobacco Regulatory Science (PDF - 12KB)

Principal Investigator:
Stephen T. Higgins, Ph.D.

Organization:
University of Vermont and State Agriculture College, Burlington

Grant Number:
P50-DA-036114-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Low Nicotine Cigarettes in Vulnerable Populations: Childbearing Age Women (PDF - 13KB)
Research Project Directors: Sarah H. Heil, University of Vermont; Stephen T. Higgins, University of Vermont

Project 2: Low Nicotine Cigarettes in Vulnerable Populations: Opioid Abusers (PDF - 13KB)
Research Project Director: Stacey C. Sigmon, University of Vermont

Project 3: Low Nicotine Cigarettes in Vulnerable Populations: Currently Depressed (PDF - 12KB)
Research Project Director: Jennifer W. Tidey, Brown University

UPENN TCORS: Tobacco Product Messaging in a Complex Communication Environment (PDF - 13KB)

Principal Investigators:
Robert C. Hornik, Ph.D., and Caryn Lerman, Ph.D.

Organization:
University of Pennsylvania, Philadelphia

Grant Number:
P50-CA-179546-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Information and Misleading Information about Tobacco Products in the "New" and "Old" Public Communication Environment: Measuring Its Presence, Estimating Its Effects, Recommending Regulatory Responses (PDF - 29KB)
Research Project Director: Robert Hornik, University of Pennsylvania

Project 2: Belief Echoes: Interventions to Correct Misleading Information about Tobacco Products (PDF - 31KB)
Research Project Director: Joseph N. Cappella, University of Pennsylvania

Project 3: Effects of Implicit Messaging by Cigarette Pack Color on Smoking Behaviors (PDF - 29KB)
Research Project Director: Andrew A. Strasser, University of Pennsylvania

Yale Tobacco Center of Regulatory Science (PDF - 11KB)

Principal Investigators:
Suchitra Krishnan-Sarin, Ph.D., and
Stephanie S. O’Malley, Ph.D.

Organization:
Yale University, New Haven

Grant Number:
P50-DA-036151-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Effects of Flavors on Nicotine Choice and Central Reward Mechanisms (PDF - 29KB)
Research Project Directors: Sven-Eric Jordt, Yale University; Marina R. Picciotto, Yale University

Project 2: Menthol’s Effects on the Nicotine Reinforcement in Smokers (PDF - 30KB)
Research Project Director: Mehmet Sofouglu, Yale University

Project 3: Flavors and E-cigarette Effects in Adolescent Smokers (PDF - 30KB)
Research Project Director: Suchitra Krishnan-Sarin, Yale University

Project 4: Economics, Experiments and PATH Data: Creating Knowledge for Tobacco Regulation (PDF - 30KB)
Research Project Director: Jody L. Sindelar, Yale University

Pennsylvania State University Tobacco Center of Regulatory Science (TCORS) (PDF - 11KB)

Principal Investigators:
Joshua E. Muscat, Ph.D., and
Jonathan Foulds, Ph.D.

Organization:
Penn State College of Medicine/Penn State Milton S. Hershey Medical Center, Hershey

Grant Number:
P50-DA-036107-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Switching to Progressively Reduced Nicotine Content Cigarettes in Smokers with Lower Socioeconomic Status
Research Project Director: Joshua E. Muscat, Pennsylvania State University (PDF - 9KB)

Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety Disorders (PDF - 10KB)
Research Project Directors: Jonathan Foulds, Pennsylvania State University; Eden A. Evins, Harvard University

Project 3: Free Radical Exposure and Oxidative Stress from Conventional and Reduced Nicotine Cigarettes (PDF - 11KB)
Research Project Director: John Richie, Pennsylvania State University

USC Tobacco Center of Regulatory Science (TCORS) for Vulnerable Populations (PDF - 12KB)

Principal Investigators:
Mary Ann Pentz, Ph.D., and
Jonathan M. Samet, M.D.

Organization:
University of Southern California, Los Angeles

Grant Number:
P50-CA-180905-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Diffusion of Marketing Messages about Tobacco Products through Social Media (PDF - 30KB)
Research Project Directors: Jennifer Unger, University of Southern California; N. Tess Boley Cruz, University of Southern California

Project 2: Maximizing Retailers’ Responsiveness to FDA Regulatory Authority in Minority Communities (PDF - 30KB)
Research Project Director: Lourdes Baezconde-Garbanati, University of Southern California

Project 3: Adolescent Smoking: Vulnerability to Tobacco Use and Marketing across Life (PDF - 30KB)
Research Project Director: Rob McConnell, University of Southern California

Tobacco Center of Regulatory Science on Youth and Young Adults (PDF - 11KB)

Principal Investigator:
Cheryl L. Perry, Ph.D.

Organization:
The University of Texas Health Sciences Center, Houston

Grant Number:
P50-CA-180906-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Texas Adolescent Tobacco and Marketing Surveillance Study (TATAMS) (PDF - 30KB)
Research Project Director: Melissa H. Stigler, The University of Texas Health Sciences Center at Houston

Project 2: Tobacco marketing and Alternative Tobacco Use among College Students (PDF - 30KB)
Research Project Directors: Alexandra Loukas, The University of Texas at Austin

Project 3: Informing and Correcting Perceptions Regarding Tobacco Products in Young Adults (PDF - 30KB)
Research Project Director: Alexander V. Prokhorov, The University of Texas MD Anderson Cancer Center

Effective Communication on Tobacco Product Risk and FDA Authority (PDF - 12KB)

Principal Investigator:
Kurt M. Ribisl, Ph.D.

Organization:
University of North Carolina at Chapel Hill

Grant Number:
P50-CA-180907-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Communicating the Risks of Harmful Cigarette Smoke Constituents (PDF - 30KB)
Research Project Director: Noel T. Brewer, The University of North Carolina at Chapel Hill

Project 2: Effective Risk Communication on New and Emerging Tobacco Products (PDF - 30KB)
Research Project Director: Erin L. Sutfin, Wake Forest University

Project 3: Enhancing Source Credibility in Tobacco Regulatory Communications (PDF - 30KB)
Research Project Director: Adam O. Goldstein, The University of North Carolina at Chapel Hill

OSU Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) (PDF - 13KB)

Principal Investigators:
Peter G. Shields, M.D., and
Mary Ellen Wewers, Ph.D.

Organization:
The Ohio State University, Columbus

Grant Number:
P50-CA-180908-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: Urban and Rural Male Youth Cohort Study of Tobacco Use (PDF - 30KB)
Research Project Director: Amy Ferketich, The Ohio State University

Project 2: Understanding Adolescent Trajectories, Exposures and Susceptibilities (PDF - 30KB)
Research Project Director: Peter G. Shields, The Ohio State University

Project 3: Diversity of Tobacco Products Used and Purchased (PDF - 30KB)
Research Project Director: Mary Ellen Wewers, The Ohio State University

Project 4: Comprehension of Health Risks in More and Less Arousing Affective Contexts (PDF - 30KB)
Research Project Director: Ellen Peters, The Ohio State University

The Impact of Tobacco Exposure on the Lung’s Innate Defense System (PDF - 12KB)

Principal Investigator:
Robert Tarran, Ph.D.

Organization:
University of North Carolina at Chapel Hill, School of Medicine.

Grant Number:
P50-HL-120100-01

FOA:
RFA-DA-13-003

Fiscal Year Awarded:
FY 2013

Project 1: The Effects of New and Emerging Tobacco Products on Lung Hydration and Inflammation (PDF - 30KB)
Research Project Director: Robert Tarran, The University of North Carolina at Chapel Hill

Project 2: The Effects of Tobacco Exposure on the Airway Mucus/Mucin Integrity and Proteome: Determining the Tobacco Mucomarkers (PDF - 30KB)
Research Project Director: Mehmet Kesimer, The University of North Carolina at Chapel Hill

Project 3: Mouse Models of Smoking-related Diseases: What is the Best Mimic of Human Disease? (PDF - 53KB)
Research Project Director: Claire M. Doerschuk, The University of North Carolina at Chapel Hill

Project 4: Translational Studies to Identify Epithelial Biomarkers of Smoke Exposure (PDF - 30KB)
Research Project Director: Ilona Jaspers, The University of North Carolina at Chapel Hill