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The Role of Opioids in the Treatment of Chronic Pain, Pathways to Prevention. September 29-30, 2014

Monday, September 29, 2014

8:30 a.m. Welcome
Nora D. Volkow, M.D.
Director
National Institute on Drug Abuse
National Institutes of Health
8:45 a.m. Opening Remarks
Story C. Landis, Ph.D.
Director
National Institute of Neurological Disorders and Stroke
National Institutes of Health
9:00 a.m. Charge to the Panel
David M. Murray, Ph.D.
Associate Director for Prevention
Director
Office of Disease Prevention
Division of Program Coordination, Planning, and Strategic Initiatives
Office of the Director
National Institutes of Health
9:10 a.m. Workshop Overview and Panel Activities
David B. Reuben, M.D.
Chief
Division of Geriatrics
Director
Multicampus Program in Geriatric Medicine and Gerontology
Professor of Medicine
Division of Geriatrics
David Geffen School of Medicine at the University of California,
    Los Angeles
9:20 a.m. Overview of Topic
David A. Thomas, Ph.D.
Deputy Director
Division of Clinical Neurosciences and Behavioral Research
National Institute on Drug Abuse
National Institutes of Health
9:40 a.m. The Folly of Trying to Speak for the 100 Million
Myra Christopher, L.H.D. (Hon.)
Kathleen M. Foley Chair for Pain and Palliative Care
Center for Practical Bioethics
10:00 a.m. Clinician Perspective
David J. Tauben, M.D.
Clinical Associate Professor
Department of Medicine
Chief (Interim)
Division of Pain Medicine
Medical Director
Center for Pain Relief
University of Washington
I. What is the long-term effectiveness of opioids?
10:20 a.m. Evidence-based Practice Center I: Overview of Systematic Review Methodology and What Is the Long-Term Effectiveness of Opioids?
Roger Chou, M.D., FACP
Director
Pacific Northwest Evidence-based Practice Center
Professor of Medicine
Department of Medical Informatics & Clinical Epidemiology
Oregon Health & Science University
10:50 a.m. What Is The Long-Term Effectiveness of Opioids: Interpretation of Evidence
Jayne C. Ballantyne, M.D.
Professor, Retired
Department of Anesthesiology and Pain Medicine
University of Washington
11:10 a.m. Understanding the Data: Efficacy, Effectiveness, and Generalizability
Russell K. Portenoy, M.D.
Chief Medical Officer
Metropolitan Jewish Health System (MHJS) Hospice and Palliative Care
Director
MJHS Institute for Innovation in Palliative Care
Professor of Neurology
Albert Einstein College of Medicine
11:30 a.m. Break
11:50 a.m. Predicting Individual Differences in Opioid Analgesic Effectiveness
Stephen Bruehl, Ph.D.
Professor
Department of Anesthesiology
Vanderbilt University School of Medicine
12:10 p.m. Are Opioids Preferentially Effective in Treating Different Underlying Mechanisms of Chronic Pain?
Daniel J. Clauw, M.D.
Professor of Anesthesiology, Medicine and Psychiatry
Director
Chronic Pain and Fatigue Research Center
University of Michigan Medical Center
12:30 p.m. Lunch (to be provided at the expense of the attendee)
1:30 p.m. Discussion
II. What are the safety and harms of opioids in patients with chronic pain?
2:20 p.m. Evidence-based Practice Center II: What Are the Safety and Harms of Opioids in Patients With Chronic Pain?
Judith Turner, Ph.D.
Professor
Department of Psychiatry and Behavioral Sciences
University of Washington
2:40 p.m. Adverse Drug Reactions with Opioid Analgesic Use in Older Adults
Joseph T. Hanlon, Pharm.D., M.S.
Professor
Division of Geriatrics/Gerontology
Department of Medicine
University of Pittsburgh School of Medicine
3:00 p.m. Prescription Opioids and Substance Use Disorder
Edward C. Covington, M.D.
Director
Neurological Center for Pain
Cleveland Clinic
3:20 p.m. Risks of Opioid Therapy
Nathaniel P. Katz, M.D., M.S.
President and Chief Executive Officer
Analgesic Solutions
Adjunct Assistant Professor of Anesthesia
Tufts University School of Medicine
3:40 p.m. Public Health Impact
Jane C. Maxwell, Ph.D.
Senior Research Scientist
Addiction Research Institute
University of Texas at Austin School of Social Work
4:00 p.m. Discussion
5:00 p.m. Adjourn

Tuesday, September 30, 2014

III. What Are the Effects of Different Opioid Management Strategies?
8:30 a.m. Evidence-based Practice Center Presentation III: What Are the Effects of Different Opioid Management Strategies?
Roger Chou, M.D., FACP
Director
Pacific Northwest Evidence-based Practice Center
Professor of Medicine
Department of Medical Informatics & Clinical Epidemiology
Oregon Health & Science University
8:50 a.m. Selected Strategies To Optimize Opioid Therapy and Decrease Risk of Abuse: State of the Evidence
Ricardo A. Cruciani, M.D., Ph.D.
Director
Center for Comprehensive Pain Management and Palliative Care
Capital Institute for Neuroscience
Capital Health Medical Center
9:10 a.m. Effectiveness of Treatment Strategies for Managing Patients With Addiction to Prescription Opioids on Outcomes Related to Addiction, Abuse, Misuse, Pain, Function, and Quality of Life
Steven D. Passik, Ph.D.
Vice President
Clinical Research and Advocacy
Millennium Research Institute
Millennium Laboratories
9:30 a.m. Impact of Pharmacokinetics and Pharmacodynamics: Relevance to Abuse and Addiction and Risks in Treatment
Sharon Walsh, Ph.D.
Professor of Behavioral Sciences, Psychiatry, Pharmacology, and
    Pharmaceutical Science
Director
Center on Drug and Alcohol Research
University of Kentucky College of Medicine
9:50 a.m. Discussion
IV. What Is the Effectiveness of Risk Mitigation Strategies for Opioid Treatment?
10:30 a.m. Evidence-based Practice Center IV: What Is the Effectiveness of Risk Mitigation Strategies for Opioid Treatment?
Judith Turner, Ph.D.
Professor
Department of Psychiatry and Behavioral Sciences
University of Washington
10:50 a.m. Risk Mitigation by Way of Naloxone
Phillip O. Coffin, M.D., M.I.A.
Director of Substance Use Research
HIV Prevention Section
San Francisco Department of Public Health
11:10 a.m. Opioid Risk Mitigation and Adherence Monitoring in Practice
Erin E. Krebs, M.D., M.P.H.
Core Investigator
Center for Chronic Disease Outcomes Research
Medical Director
Women Veterans Comprehensive Health Center
Minneapolis Veterans Administration
Associate Professor
Department of Medicine
University of Minnesota
11:30 a.m. Prescription Opioid Misuse and Addiction: A National Priority
Wilson M. Compton, M.D., M.P.E.
Deputy Director
National Institute on Drug Abuse
National Institutes of Health
11:50 a.m. Discussion
12:30 p.m. Break
12:50 p.m. Roundtable Discussion on Opioids in the Real World
Wendy B. Smith, Ph.D., M.A., BCB, Moderator
Senior Scientific Advisor for Research Development and Outreach
Office of Behavioral and Social Sciences Research
Office of the Director
National Institutes of Health

Daniel J. Clauw, M.D., Panelist
Professor of Anesthesiology, Medicine and Psychiatry
Director
Chronic Pain and Fatigue Research Center
University of Michigan Medical Center

Ricardo A. Cruciani, M.D., Ph.D., Panelist
Director
Center for Comprehensive Pain Management and Palliative Care
Capital Institute for Neuroscience
Capital Health Medical Center

Tracy W. Gaudet, M.D., Panelist
Director
Office of Patient Centered Care and Cultural Transformation
Veterans Health Administration
U.S. Department of Veterans Affairs
1:30 p.m. Workshop Wrap-Up/Next Steps
1:40 p.m. Adjourn
Attendees will be responsible for meals and/or light refreshments on their own, at their own expense. The government and/or government contractors are not involved in facilitating the provision of food and/or light refreshments.